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Principles and Architecture

How do we build design principles into the deepest architecture of things, into the algorithms and mechanisms?

It goes deeper than an ethos or mission. Those things change, get re-evaluated. Good intent can be reduced to a veneer while the core values are dismantled and exploited. 

But what if something couldn't exist at all without the complete set of design principles? Like a human body, every system present and functioning or no life at all. 

What are the means by which the architecture and the principles become inseparable? More importantly, how does this inseparability transcend enforcement and become a fundamental aspect of existence?